The Latest News
Latest news
Team Member, Margarida Espadinha, won the EFMC-YMCS public’s choice award, sponsored by Roche, with the oral communication about the development of spiropyrazoline oxindoles as dual inhibitors of p53-MDMs PPIs
September, 2022
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The team member Margarida Espadinha was awarded with public’s choice award, sponsored by Roche, presenting our latest results of the development of spiropyrazoline oxindoles as dual inhibitors of p53-MDM2/X PPIs at EFMC-YMCS 2022 in Nice, France.
Our work on the development of spiropyrazoline oxindoles as dual inhibitors of p53-MDMs PPIs presented by PhD student Elizabeth Lopes at the EFMC-ISMC 2022 (Nice)
September, 2022
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The PhD student Elizabeth Lopes presented our latest results of the development of spiropyrazoline oxindoles as dual inhibitors of p53-MDM2/X PPIs at EFMC-ISMC 2022 in Nice, France.
DD4PPI latest results on the discovery of dual inhibitors of MDM2/X were presented at the 3rd MMCS in Rome
July, 2022
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The PhD student Elizabeth Lopes presented our latest results of the discovery of new dual inhibitors of MDM2/X at the 3rd MMCS held in Rome, Italy.
Our latest results on the development of dual inhibitors of p53-MDMs PPIs presented at the 5th CQUL
July, 2022
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The PhD student Elizabeth Lopes presented our latest results of the development of spiropyrazoline oxindoles as dual inhibitors of p53-MDM2/X PPIs at 5th Colégio da Química UL: Forging Bonds held at the Rectory of the University of Lisbon.
Paulo Furtado presented our latest results on the discovery of new dual inhibitors of MDM2/X at the iMed meeting
July, 2022
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Our junior research Paulo Furtado presented our work on the discovery of new dual inhibitors of MDM2/X at iMed.ULisboa Postgraduated Students Meeting held at the Faculty of Pharmacy, University of Lisbon.
Elizabeth Lopes presented her PhD work at ESMEC
July, 2022
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During the first week of July, the PhD student Elizabeth Lopes presented her research at the 41st edition of the European School of Medicinal Chemistry held in Urbino Italy.
Recent Advances in Drug Discovery of p53 Reactivators Meeting
July, 2022
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Last July 1st we have helded the Recent Advances in Drug Discovery Meeting at Faculty of Pharmacy. We had the honour having Nuno Maulide, Mattia Mori, Ermelinda Maçôas and Catarina Roma-Rodrigues with us to share their latest results on the development of p53 reactivators.
Ricardo Ferreira and Elizabeth Lopes presented their work at 22nd Tetrahedron Symposium
June, 2022
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The research fellow Ricardo Ferreira and PhD student Elizabeth Lopes have presented posters with their work on development of reactivators of mut p53 and development of spiropyrazoline oxindoles to dual inhibit p53-MDM2/X PPIs at the 22nd Tetrahedron Symposium on june 28 - July 1, helded in Lisbon.
Recent Advances in Drug Discovery of p53 Reactivators Meeting
June, 2022
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It is with great pleasure that we announce the Recent Advances in Drug Discovery of p53 Reactivators Meeting. The meeting will be held at the Faculty of Pharmacy of the University of Lisbon on July 1st (9:00-13:00). The meeting will be onsite; promoting the discussion of results, networking between participants, and will consider several topics including:
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From synthetic chemistry to drug design
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Computer-aided design of protein-protein interaction inhibitors
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Structural insights of p53 reactivation
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Novel small molecule p53 activators
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Development of fluorescent probes
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In vitro and in vivo assays for biological characterization
The registration if free but mandatory (deadline: June 29th), as limited places are available.
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Best Regards,
Maria M. M. Santos and Alexandra Paulo
Elizabeth Lopes will attend ESMEC
May, 2022
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Elizabeth Lopes was awarded with of the grants to attend the European School of Medicinal Chemistry ESMEC, certified school of EFMC, in Urbino, on July 3-7 2022. Congratulations!
Elizabeth Lopes presented her work at UGM & CONFERENCE 2022
May, 2022
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PhD student Elizabeth Lopes have presented a poster with her work on Identification of spirooxadiazoline oxindoles with dual-stage antiplasmodial activity at UGM & CONFERENCE 2022 in Amsterdam.
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Ricardo Ferreira and Elizabeth Lopes presented our projects at Encontro Ciência 2022
May, 2022
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The research fellow Ricardo Ferreira and PhD student Elizabeth Lopes have presented their projects on development of dual MDM2/X inhibitors and development of reactivators of mut p53 at the anual meeting Encontro Ciência 2022 on May 17-18.
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Margarida Espadinha was awarded with SPQ Best PhD thesis prize
April, 2022
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Margarida Espadinha was awarded with the Portuguese Chemical Society (SPQ) prize for best phD thesis entitled Design, synthesis and biological evaluation of novel p53 activators by targeting p53 protein-protein interactions.
We are very proud of Margarida Espadinha! Congratulations.
Ricardo Ferreira presented his Master thesis
February, 2022
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Congratulations to Ricardo Ferreira, who successfully defended his master thesis entitled “Novel p53 activators for anticancer therapy”, under the supervision of Professors Maria Santos and Paula Gameiro.
Margarida Espadinha presented her PhD thesis
October, 2021
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Margarida Espadinha presented her PhD thesis entitled Design, synthesis and biological evaluation of novel p53 activators by targeting p53 protein-protein interactions.
Congratulations to Margarida!
DD4PPI project was in the latest SPQ issue
January, 2021
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An article about the Drug Discovery for p53 Protein-Protein Interactions project came out in the issue 157 of the Sociedade Portuguesa de Química magazine. Check below the article.
Valentina Barcherini won ECMC 2020 Best Presentation Award
December, 2020
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Pharmaceuticals and the Organizing Committee of ECMC2020 congratulate Valentina Barcherini, Joana Almeida, Elizabeth A. Lopes, Mi Wang, Diogo Magalhães e Silva, Mattia Mori, Shaomeng Wang, Lucília Saraiva, Maria Santos who received an award for the best presentation at ECMC2020.
Topic: Optimizing the oxazoloisoindolinone family: identification and biological evaluation of a potent and selective indole-based p53 activator in human colorectal cancer
Virtual Symposium "Drug Discovery for Anti-cancer Agents"
December, 2020
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We invite you to be part of our virtual symposium on December 23rd (9h30 am GMT).
Online registration is free and mandatory
https://forms.gle/UwYNsPMtrE5kpp9q9
Check out our speakers!
Alexandra Paulo at the 13th National Organic Chemistry Meeting/6th National Medicinal Chemistry Meeting
January, 2020
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The team member Alexandra Paulo presented a keynote entitled “Challenges in the design of oncogene and p53 expression modulators” at the 13th National Organic Chemistry Meeting/6th National Medicinal Chemistry Meeting
Maria M. M. Santos at 90 segundos de ciência
November, 2019
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Maria M. M. Santos was interviewed in 90 segundos de ciência to talk about DD4PPI project.
PhD student Elizabeth Lopes was presented DD4PPI latest results at the IV QuimBioQuim in Santiago de Compostela
October, 2019
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Our PhD student Elizabeth Lopes presented an oral communication entitled In silico study and synthesis of spiropyrazoline oxindoles to act as p53-MDMs PPI inhibitors at the IV QuimBioQuim, in Santiago de Compostela.
Congratulations to PhD student Elizabeth Lopes on winning the best flash oral presentation at the Bio.Natural Meeting
September, 2019
PhD student Margarida Espadinha was at the EFMC-ASMC'19 presenting DD4PPI results
September, 2019
Our PhD student Margarida Espadinha presented the poster entitled New small-molecule dual inhibitors of p53-MDM2/X interactions to reactivate the p53 pathway at the VIII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’19), in Athens.
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Margarida Espadinha won a EFMC grant to attend the EFMC-ASMC'19 conference
June, 2019
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Our PhD student Margarida Espadinha won EFMC grant to attend the VIII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’19) which will be helded in Athens, Greece, in September.
European Patent granted entitled "Tryptophanol-derived oxazoloisoindolinones: small-molecule p53 activators"
March, 2019
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Valentina Barcherini won best presentation prize in ECMC-4
January, 2019
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Pharmaceuticals and the Organizing Committee of ECMC-4 congratulate Valentina Barcherini, Margarida Espadinha, Joana Soares, Sara Gomes, Alexandra Antunes, Lucília Saraiva, Maria Santos who received an award for the best presentation at ECMC-4:
Topic: Enantiopure oxazoloisoindolinones: Promising small molecules for p53-based therapy with potential anticancer properties.
Design and synthesis of small molecules with enhanced anti-tumor potential
September, 2019
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Kick-off meeting of Bilateral Action FCT/NKFIH and 1st annual meeting of DD4PPI
