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Our publications

Papers in peer-reviewed international journals

"Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors", Eur. J. Med. Chem. 2022, 241, 114637

"Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity", Eur. J. Med. Chem. 2022, 236, 114324

Graphical_Abstract_updated_ME3

"Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma", Pharmaceuticals 2021, 14(3), 208

2020 Bio

"Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line", Bioorganic & Medicinal Chemistry, 2021, 30, 115880

ChemMedChem_graphical abstract

“Potency and Selectivity Optimization of Tryptophanol‐Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer”, ChemMedChem 2021, 16, 250.

ijms_grafical abstract

“SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner”, Int. J. Mol. Sci., SPECIAL ISSUE: p53 in Cancer and beyond—40 Years after Its Discovery 2020, 21 (2), 596

BBA_grafical abstract

"SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations", Biochimica et Biophysica Acta (BBA) - General Subjects, 2020, 1864, 129440

Graphical abstract

"Small Molecules Targeting Mutant P53: A Promising Approach for Cancer Treatment", Curr. Med. Chem. 2019, 26, 1-13

cancers_graphical abstract

"SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma", Cancers 2019, 11(8), 1151

frontires

“A novel small molecule p53 stabilizer for brain cell differentiation”, Frontiers in Chemistry 2019, 7, article 15.

2018 BritJPharm

"Improving anticancer activity towards colon cancer cells with a new p53-activating agent", Br J Pharmacol, 2018, 175(20), 3947-3962

Curr_graphical abstract

“An Update on MDMX and Dual MDM2/X Inhibitors”, Curr. Top. Med. Chem. 2018, 18, 647-660.

Book Chapter

Synthetic Approaches to Nonaromatic Nitrogen Heterocycles

Synthesis of spirooxindoles by multicomponent reactions. In: Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, Volume 1, ed. A. Phillips, Wiley, 2020, chapter 9, 225-247

Small Molecule Drug Discovery: Methods, molecules and applications

PPIs as therapeutic targets for anti-cancer drug discovery: the case study of MDM2 and BET bromodomain inhibitors. In: 'Small Molecule Drug Discovery: Methods, molecules and applications, ed. A. Trabocchi, E. Lenci, Elsevier, 2019, chapter 10, 267-283.

©2020 by Drug Discovery for p53 PPI-targets.

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