Our Research

The objectives of DD4PPI are to obtain innovative inhibitors of p53 protein-protein interactions in a research framework where excellent science is created by combining computational chemistry, organic synthesis, biology and toxicology.

The rational drug design approach for the synthesis of the inhibitors will involve:

1.  Lead generation and optimization for drug discovery of p53 protein-protein interaction (PPI) inhibitors;

2.  Innovative synthetic methodologies to prepare the small molecule inhibitors based on indole scaffolds;

3.  Screening of compounds as p53 activators;

4.  Stability studies of the most promising compounds.

The proposed work plan encompasses a multi-disciplinary team with the required expertise to develop novel libraries of indole-based compounds that are dual inhibitors of p53-MDM2/X protein-protein interactions.